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Cambridge Isotope Laboratories, Inc. (CIL) Launches Stable Isotope-Labeled and Unlabeled TCA Cycle Multi-Component Mixes

Cambridge Isotope Laboratories, Inc.

Cambridge Isotope Laboratories, Inc. (CIL) Launches Stable Isotope-Labeled and Unlabeled TCA Cycle Multi-Component Mixes

TEWKSBURY, Mass., Oct. 06, 2021 (GLOBE NEWSWIRE) — Cambridge Isotope Laboratories, Inc. (CIL) is pleased to announce the release of our new stable isotope-labeled and unlabeled TCA cycle mixes to aid in the analysis of TCA-associated compounds in metabolic studies. The TCA (tricarboxylic acid) cycle, also known as the Krebs or citric acid cycle, plays an essential role in central carbon and energy metabolism. The study of its intermediates, and its ancillary compounds, has proven pivotal in not only understanding their impact on metabolism but also in profiling their function in oncogenesis, inflammation, and other pathologies.

Krista Backiel, CIL’s Director of Business Development and Strategic Marketing, Life Sciences, states: “These new mixes enable researchers to easily identify and quantify multiple TCA cycle analytes in Mass Spectrometry (MS)-based methods. They were carefully designed to reduce researcher development time, enhance data quality, and streamline MS applications.”

The target audience for these mixes includes researchers performing qualitative and quantitative metabolomic analyses, those studying central carbon metabolic profiling, and those performing metabolic flux analysis.

Ashley Sidebottom, Ph.D., Metabolomics Platform Director, University of Chicago (USA) Host-Microbe Metabolomics Facility, Duchossois Family Institute stated: “The metabolomic compound mixes by Cambridge Isotope Laboratories have expedited several processes in our GC-MS analysis pipeline. We have used these products, including their novel TCA mixes, to verify metabolite retention times, test derivatization reaction conditions, and to confirm fragmentation patterns detected in biological samples. CIL’s metabolite mixes are ready to go, easy to use, and consistently of high quality!”

The TCA mixes are dried down and comprise a total of 13 metabolites, with 6 being direct TCA cycle intermediates (e.g., α-ketoglutarate, succinate) and 7 being important offshoot metabolites (e.g., itaconate and 2-hydroxyglutarate). The isotope-labeled and unlabeled TCA mixes can be purchased individually or as a set, depending on the need of the researcher. They are currently all in stock and available for global distribution.

To learn more about CIL’s new TCA Cycle mixes, visit isotope.com.

About Cambridge Isotope Laboratories, Inc.

CIL is the world’s largest manufacturer and global supplier of stable isotopes and stable isotope-labeled compounds used in research, environmental, neonatal, pharmaceutical, medical diagnostic, OLED, and industrial markets. CIL is an operating business owned by Otsuka Pharmaceuticals. The CIL business consists of two facilities in the Boston, MA, area; a large isotope-enrichment production plant in Xenia, OH; CIL China; CIL Canada; ABX in Dresden, Germany; and Eurisotop in Saclay, France.

For more information on CIL, visit isotope.com.

Contact Information:
Crissy Krisko
Phone: 1.978.749.8000
Fax: 1.978.749.2768

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Cambridge Isotope Laboratories, Inc.
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Default Risk in USD 4.86 Trillion Global FX Gross Payments Can be Mitigated by Webtel.mobi’s System

WM’s 21st Century system provides a solution to the increasing risks to global security that the continual rise in unsecured FX Transactions are introducing to the Global Financial System

ST PETER PORT, Guernsey and NEW YORK, Oct. 06, 2021 (GLOBE NEWSWIRE) — Global FX Market trading amounts to US$6.6 Trillion per day or +/-US$1,716 Trillion per annum – but that number is applicable only to the Trading – and not the Gross Payment obligations arising from that trading.

The Gross Payment obligations are US$18.7 Trillion per day or US$4,862 Trillion per annum.

According to the Bank for International Settlements (“BIS”) Quarterly Review of 2019, almost half that US$4.86 Trillion per annum is at risk of default, due to it not being covered by any secured “Payment versus Payment” (PvP) structure.

Although most people who are not involved in the FX or related markets at a high level are not familiar with these markets, market values or the terms used for these transactions – they should be. This is because any default in these markets – and the risk of default grows every year – will affect every person and business in the world very seriously.

The 2008 Financial Crisis was also the result of a default. A different market – but the same process of default. A default in the Gross Payments process of the Global FX Market will cause a much more serious crisis than in 2008, because the volumes and values involved in this default will be very much higher.

Moreover, defaults initiate chain reactions – just as Facebook’s outage caused a chain reaction that saw many non-Facebook sites to go down, or business hosted on Facebook to experience problems – and these would reverberate globally and significantly.

For the average person or business, a default in the Gross Payment obligations of the FX Market will have far more serious consequences than the 2008 Financial Crisis – one of the largest financial crises in history.

The reason is the advent of 21st Century technology has enabled far more entities internationally to become involved in Global FX Trading. However, the entities primarily responsible for the Settlement of FX Trades are not 21st Century companies. Rather, they are 20th Century companies – with some of them functioning according to 19th Century methodologies or world-views.

This situation is, in its current format, insoluble given the structure of the incumbent settlement companies – and that they cannot stop their operations to rebuild their systems to conform to 21st Century requirements.

WM, on the other hand, built its first platform – Platform 1 – to fit with the changed and modernized landscape that 21st Century Technologies provided, and tested that platform robustly in worldwide operations for nine years.

Thereafter, WM completely rebuilt its platform to conform to modern best practice structures, process-flows and capacities as dictated by its nine years of operational testing, to produce its Complex Adaptive System-driven Platform 2 – which is specifically built to cater for 21st Century capacities and requirements.

An overview comparison of some of the capacity-differences between the legacy systems and the WM System are as follows:

Process Flows
The process-flow in such transactions involves three processes – Execution, Clearing and Settlement.

Legacy Systems: Legacy systems each have 70 to 100 Settlement Member entities that jointly work together to provide these services to 25,000 or more transacting entities worldwide. However, all of these entities – whether Settlement or Transacting – are in different countries, in different time zones, with different internal processes, with varying standards of security, reliability and speed – with hundreds of intermediaries involved in the process. This makes it (comparatively) a very high-cost process. It was necessary to work this way in the 20th Century because there was no other alternative. In the 21st Century – with the capacity for entities globally do conduct transactions worldwide in seconds – this system is so fragmented that it cannot function in any way than “best efforts”. It requires patches and contingencies continually having to be used to cater for the multitude of problems caused by such a huge number of required entities and their varying capacities trying to work together. It is just a matter of time before the “best efforts” and patches run out of the capacity to keep the system afloat.

WM’s System: Execution, Clearing and Settlement is all carried out simultaneously and instantly – in 1/100th of a second – to all, and any, member entities globally, according to uniform and global standards of speed, security, reporting and recording. There are no intermediaries or other entities involved at all, and the cost is either 0.25% to 1% if using WM’s ICLM Currency Swap facility or zero if using WM’s TUV Currency Swap Facility.

There are two types of default risk. The first is Default Risk – where an entity does not have the funds it claims to have and cannot settle. The second is Settlement Timing Risk that leads to Default – where an entity may have the capacity to acquire the funds, but cannot acquire them in time to settle (i.e., leveraged trading).

Legacy Systems: Legacy Systems are rarely exposed to Default Risk, but they are increasingly in danger of being subjected to Settlement Timing Risk due to more entities engaging in leveraged trading – meaning they carry out FX Trading as liquidity providers without actually having the funds available to cover total exposure. As an indication of how dangerous Settlement Timing Risk is, the 2008 Financial Crisis was caused by it.

WM’s System: WM’s System’s process-flow completely removes both Default Risk and Settlement Timing Risk. All members must have 100% of required funding (as “Stored Credit”) within their accounts prior to executing either an ICLM Currency Swap or TUV Currency Swap, and the Execution, Clearing and Settlement between both parties to the transaction is instantaneous.

Currencies and Timings
Legacy Systems: Currently, Legacy Systems only provide Settlement in the World’s Reserve Currencies (this varies between 18 to 20 currencies depending on the entity) and none of the other 100+ currencies – for which trades, and Gross Payment Obligations are mostly not PvP secured. Moreover, their limited 24/5/365 operational times and the wide disparity in time zones, standards and processes of the tens-of-thousands of entities and intermediaries involved in the processes cause delays to arise in transmission of settlements.

WM’s System: WM’s system provides for the World’s Reserve Currency and nearly 30 others – and is increasing the currencies it caters for rapidly – in order to cover all world currencies. It functions 24/7/365, and its transactions flows for receipt and settlement to all parties in a transaction are instant.

The Recommendations of the Group of 30
As long ago as 2003, an organization known as the “Group of 30” – an eminent persons group comprising former senior members of Central Banks, Large Commercial Banks, and International Financial organizations – published a research paper entitled “Global Clearing and Settlement – A Plan of Action”.

This document described in detail the alarming fragility of the Global Clearing and Settlement systems at that time, and the grave peril that failure to attend to these shortcomings could bring to the entire Global Financial and Economic systems.

In the document, they published a list of 20 very clear requirements for the reform and stabilization of these systems globally.

To date – and despite the situation in respect of stability worsening since then – not one of those 20 requirements has been able to be achieved by any of the legacy systems.

The WM System has – on the other hand – not only conforms to, and has, all the 20 requirements as part of its System, it surpasses them (with the exception of securities lending and borrowing – as WM has electively decided not to include this type of facility on its platform at this time).

Currently, WM is the only entity globally whose structure is built to – and has the capacity to – adequately cater for the security of the Global Clearing and Settlement Markets – for the Global FX Market and a variety of other markets whose sizes and volumes are similar – in a manner conformant with 21st Century requirements.

(Notes: Links to the BIS Report on FX Settlement Risk document and the Group of 30’s document containing its 20 recommendations are available in the “Resources” section below)


Media Contact:
Nick Lambert: wm@thoburns.com

BIS Quarterly Review – FX Settlement Risk Remains Significant:

Group of 30 – Global Clearing and Settlement, A Plan of Action:

Research Reports on the Capacities of the WM System:

Video on the Capacities of the WM System:

Video on WM’s Regulatory Compliance:

WM’s urls:
https://webtel.mobi/pc (Tablets / Laptops / Desktops)
https://webtel.mobi (Smart Phones)
https://webtel.mobi/wap (Pre-Smart Mobile Phones)

YellowBlocks officially announced the TOP 6 Vietnamese representatives to join the International Blockchain Olympiad (IBCOL 2021)

Final announcement of VN-BCOL 2021

Final announcement of VN-BCOL 2021

HO CHI MINH CITY, Vietnam., Oct. 06, 2021 (GLOBE NEWSWIRE) — The National Pitch Day for IBCOL 2021 – Vietnam National Selection Round (VN-BCOL) was held by YellowBlocks – Head of the National Organizing Committee, and the co-organizers: Hub Global, National Startup Support Center (Ministry of Science & Technology), RedFox Labs, and LaunchZone. This is the second time Vietnam has participated in the competition along with +59 countries from the Americas, Asia-Pacific, Europe, Middle East.

After two months, VN-BCOL acquired +100 whitepaper submissions from Vietnamese students across the country. Over 1,500 audiences watched the event online. Top three finalists won prizes totaling $5,000, awarded by RedFox Labs. Top 6 finalists were nominated as the Vietnamese representatives to participate in the Final Global Round.

  • Champion: LifeLink – “A blockchain-based platform using Federated Learning to empower AI in medical research without centralizing and sharing patient data”.
  • 1st Runner-up: KidKat – “Blockchain-based Children Trafficking Prevention System”.
  • 2nd Runner-up: DLA Squad – “A Blockchain Application for Electric Vehicles Battery Leasing Service Management”.
  • Merit Awards: The Blockers – “Certchain”; Trang Le – “Blockchain Technology In Healthcare”; ViFaChain – “Vietnamese Food Export Traceability & Quality Management System”.

Kimiko Doan, YellowBlocks’s Founder, Head of the National Organizing Committee commented: “This year’s projects are of great quality, showing the contestant’s academic knowledge and ability to utilize blockchain in practice. Following the National Pitch Day, we will head to the Mentoring Round where contestants are given the opportunity to connect with and be mentored by leading blockchain experts.”

Ben Fairbank, RedFOX Labs’ Founder commented: “RedFOX Labs is thrilled to be a part of VN-BCOL. The Vietnamese talent is something the whole country can be proud of, and we look forward to seeing Vietnam represented on the world stage. RedFOX Labs launches companies in the fastest growing sectors of the internet economy, so we are well versed in what a company must overcome to go to market and be successful. We take great pride in helping to unearth the next big companies out of Vietnam.”

The International Blockchain Olympiad (IBCOL) is an annual global competition that invites current and recent students to propose complete solutions for real-world problems with blockchain technology. IBCOL 2021 will be held online from October 8-10, 2021.

Media contact: hello@yellowblocks.org | Website: https://yellowblocks.org

A photo is available at: https://www.globenewswire.com/NewsRoom/AttachmentNg/fa799490-25e1-441a-b57f-4be7d86c9423

Singapore to Leverage the Global Cyber Alliance’s IoT Threat Analytics Platform

GCA’s Automated IoT Defence Ecosystem provides early warnings on IoT cyberattacks

SINGAPORE and NEW YORK, Oct. 06, 2021 (GLOBE NEWSWIRE) — Today, the Cyber Security Agency of Singapore (CSA) has announced that it will partner with the Global Cyber Alliance (GCA) to leverage the capabilities of GCA’s Automated IoT Defence Ecosystem (AIDE) platform to monitor and address IoT threats and safeguard the cybersecurity of the IoT space. The project will be the first large-scale application of the AIDE platform.

The global number of IoT devices is expected to rise to more than 50 billion by 2030. This presents a huge attack surface for malicious actors, which may lead to consequences like the theft of personal data and the disruption of services using IoT devices as botnet nodes to conduct distributed denial of service (DDoS) attacks. There is a need to proactively watch for global IoT threats and attack data, so that nations can be better prepared before the next wave of botnet attacks hit their shores.

The IoT threat analytics platform can provide CSA visibility on the types of IoT-related cyber threats that may affect the country’s cyberspace. The insights from the platform allow partners to put in place policies and technical measures to safeguard against threat vectors through the conduit of IoT devices. The result is a better prepared and safer IoT cyberspace.

“The use of IoT devices is growing exponentially. CSA has introduced several initiatives to improve IoT security, including the world’s first multi-level labelling scheme for consumer IoT devices— the Cybersecurity Labelling Scheme. This latest initiative —our partnership with GCA on AIDE— will help us be better prepared against potential IoT attacks. Cybersecurity is a team sport where everyone has a part to play. CSA will continue to work with stakeholders to look for ways in building a more resilient and secure IoT space,” said Mr. David Koh, Commissioner of Cybersecurity and Chief Executive of CSA.

GCA’s AIDE ecosystem is a central component of the project. This large repository of IoT threat intelligence relies on a globally distributed honeyfarm and on data feeds from partners.

According to Mr. Philip Reitinger, President and CEO of GCA, “This is a unique opportunity to increase GCA’s international collaboration and expand our network of partners, from cybersecurity agencies and large internet players to academia and research institutions. This project —and CSA’s support as a whole— is a crucial milestone in our roadmap for the AIDE ecosystem and in our long-term vision on IoT cybersecurity. The fact that this effort is happening in Singapore, a global flagship for technology, will pave the way to expand the initial scope of the project to other international smart cities.”

To learn more about AIDE visit: https://www.globalcyberalliance.org/aide/.

About the Global Cyber Alliance
The Global Cyber Alliance (GCA) is an international, cross-sector effort dedicated to reducing cyber risk and improving our connected world. We achieve our mission by uniting global communities, implementing concrete solutions, and measuring the effect. GCA, a 501(c)(3) in the US and a non-profit in the UK and Belgium, was founded in September 2015 by the Manhattan District Attorney’s Office, the City of London Police, and the Center for Internet Security. Learn more at www.globalcyberalliance.org.

Contact at GCA:
Alejandro Fernández-Cernuda Díaz
Director of Engagement, Internet Integrity Program

BrightVolt Raises $16 Million in Series B Funding Led by New Science Ventures and Caterpillar Venture Capital Inc.

BrightVolt Solid State Power Solutions

BrightVolt Solid State Power Solutions

REDMOND, Wash., Oct. 06, 2021 (GLOBE NEWSWIRE) — BrightVolt, Inc., a global leader in the design, development, and manufacturing of safe, high energy and low cost solid-state Lithium-Ion batteries has successfully closed the first tranche of a $16M Series B financing round with significant investments by New Science Ventures (NSV) and Caterpillar Venture Capital Inc. (Caterpillar). Fresh funds will be utilized for development of larger form factor products targeting industrial electrification and e-mobility markets.

Caterpillar is supporting customers during the energy transition to a reduced-carbon future through investments in new products, technologies and services. The company currently offers battery-powered equipment for the mining, construction, energy and transportation industries and recently announced seven sustainability goals to achieve by 2030, including that 100% of Caterpillar’s new products through 2030 will be more sustainable than the previous generation.

“BrightVolt’s core polymer matrix electrolyte technology (PME®) has demonstrated a lot of promise in terms of its performance, and we’re excited to participate in this investment round,” said Jihad Salahuddin, Caterpillar Senior Investment Manager. “BrightVolt’s innovative approach to manufacture solid-state Lithium-Ion batteries, utilizing their PME® technology, is compatible with existing roll-to-roll Lithium-Ion manufacturing lines requiring very minor capital refinements, while achieving a considerable improvement in several performance metrics.”

“Caterpillar has a long-standing commitment to sustainability. We are excited to collaborate with them on developing next-generation, solid-state Lithium-Ion batteries as another step on their path to help customers achieve their climate-related objectives,” noted Todd Peters, CEO, Chairman.

The industrial battery market was estimated at $9.0B in 2020 and is anticipated to grow to $30.8B by 2030, registering a CAGR of 13.2% from 2021 to 2030.

“BrightVolt has taken a unique approach to developing a novel polymer solid-state electrolyte for Lithium-Ion batteries,” noted Somu Subramaniam, Managing Partner at NSV. “With a strong leadership team in place, the company is targeting commercialization of Lithium-Ion batteries utilizing its proprietary polymer electrolyte technology in several key applications that have realized their theoretical limitations with use of traditional Lithium-Ion batteries like e-mobility.”

Having already sold more than 15 million primary solid-state batteries globally, BrightVolt is now bringing truly novel advances to the rechargeable battery markets, making safe, high energy and low-cost solid-state batteries a reality. With a clear target set by the Biden administration for 50% of all new car sales in the United States to be electric vehicles by 2030, BrightVolt will have the ideal battery technology in place to power this mass adoption.

About New Science Ventures

New Science Ventures, LLC (NSV), is a leading venture capital firm focused on building companies that leverage breakthrough science to create extraordinary value. NSV invests in companies using science-based innovations to address market needs in Life Sciences and Technology sectors. For more information, visit https://www.newscienceventures.com/

About Caterpillar Venture Capital Inc.

Caterpillar Venture Capital Inc. assists entrepreneurs and startups around the world to grow and scale their businesses to build today for a better tomorrow by leveraging Caterpillar’s industry expertise, supply base, and independent dealer network. Caterpillar Venture Capital’s focus areas of investment include robotics, energy, advanced materials, and digital solutions that help its customers be successful. Caterpillar Venture Capital is a wholly-owned subsidiary of Caterpillar Inc., the world’s leading manufacturer of construction and mining equipment, diesel and natural gas engines, industrial gas turbines, and diesel-electric locomotives. For more information, visit https://www.caterpillar.com

About BrightVolt, Inc.
BrightVolt’s mission is to improve the world through higher-performing battery chemistries. With a Research and Development Center in Indiana and corporate headquarters in Redmond, Washington, BrightVolt is constantly challenging the limits of chemistry, physics, and manufacturing science to support safer, healthier and more powerful new product innovations. BrightVolt’s Rechargeable solid-state batteries can power a broad range of applications including hybrid and electric vehicles as well as consumer electronics such as smartphones, laptops, e-readers, drones, medical and wearable devices along with other IoT products. To date, BrightVolt has sold over 15 million primary solid-state batteries with customers on every continent in a wide variety of industries including medical, automotive, industrial, and consumer products. For more information, visit https://www.brightvolt.com

# # #

Company Contact:

Salil Soman

BrightVolt, Inc.


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Radisson Hotel Group Relies on Freshworks to Delight its Distributed Workforce with Exceptional IT Service

The efficiency of the Freshservice ITSM solution accelerated the global hotel group’s digital transformation efforts

SAN MATEO, Calif. and LONDON, Oct. 06, 2021 (GLOBE NEWSWIRE) — Freshworks Inc. (NASDAQ: FRSH), a leading software company empowering businesses to delight their customers and employees, has helped Radisson Hotel Group improve IT efficiencies and increase response time within its distributed workforce, by using the IT service management (ITSM) solution Freshservice®.

With nine distinctive brands and more than 1,600 hotels in operation and under development, Radisson Hotel Group is one of the largest hotel chains in the world. As part of its strategic five-year plan, the company is undertaking a digital transformation, in which a number of key functions are being unified in centres of excellence. One of those centres of excellence focuses on revenue management. The Revenue Systems Hub for the 560 EMEA hotels in operation is located in Madrid and selected Freshservice to manage the team’s workflow more efficiently.

As the hospitality industry worldwide collectively adapted to mitigate the effects of the pandemic, Radisson Hotel Group’s EMEA revenue management team was forced to quickly adapt their IT infrastructure to handle a nearly 100% remote workforce while they continue to provide their customers with an omnichannel information across third party hotel booking sites, their call center and website.

Benjamin Muratet, vice president of RevTech and Distribution at Radisson Hotel Group said, “Multiple IT systems are involved in optimizing the price and occupancy of hotels by presenting the right price to the right customer at the right time and through the right channel. My team receives forty to fifty service requests per day – from simple applications to technically complex challenges. We selected Freshservice to gain more real-time insight into the IT workload and also to better distribute the work.”

The ease and automation of Freshservice enabled the Radisson Hotel Group team to view information in a structured and more complete manner, eliminating the need for emails and massively helped to reduce the turnaround time for employee service requests.

“Radisson Hotel Group’s use of Freshworks technology is the embodiment of our ‘Delight made easy’ vision,” said Prakash Ramamurthy, chief product officer of Freshworks. “The ease of use and flexibility of our products, right-sized to a customer’s unique situation, is what we do best.”

Benjamin Muratet concludes, “The emphasis is now on efficiency, even more than it was before. In addition, the team is working partially from the office as well as from home. If you want to organise the work well, transparency and structure is a prerequisite. Freshservice helps deliver that transparency. Our face-to-face work meetings are now used for strategic discussions, rather than to distribute the workload, which we now do in Freshservice.”

Learn more about how Radisson Hotel Group partners with Freshworks by reading the case study.

About Freshworks

Freshworks makes it fast and easy for businesses to delight their customers and employees. We do this by taking a fresh approach to building and delivering software that is affordable, quick to implement, and designed for the end user. Headquartered in San Mateo, California, Freshworks has a dedicated team operating from 13 global offices to serve 50,000+ customers including Bridgestone, Chargebee, DeliveryHero, ITV, Klarna, Multichoice, OfficeMax, TaylorMade and Vice Media. For more information visit www.freshworks.com.

© 2021 Freshworks Inc. All rights reserved. Freshworks, Freshservice and the associated logos are trademarks or registered trademarks of Freshworks Inc. All other company, brand and product names may be trademarks or registered trademarks of their respective companies.

About Radisson Hotel Group

Radisson Hotel Group is one of the world’s largest hotel groups with nine distinctive hotel brands, and more than 1,600 hotels in operation and under development in 120 countries. The Group’s overarching brand promise is Every Moment Matters with a signature Yes I Can! service ethos.

The Radisson Hotel Group portfolio includes Radisson Collection, Radisson Blu, Radisson, Radisson RED, Radisson Individuals, Park Plaza, Park Inn by Radisson, Country Inn & Suites by Radisson, and prizeotel brought together under one commercial umbrella brand Radisson Hotels.

More than 100,000 team members work at Radisson Hotel Group and at the hotels licensed to operate in its systems. For more information, visit our corporate website. Or connect with Radisson Hotels on: LinkedInInstagramTwitterFacebook, YouTube.

Media contact:

Abigail Watts


Radboud university medical center study sets new milestone with 90% diagnostic accuracy of lung nodules suspected of cancer using Philips technology for bronchoscopic procedures

October 4, 2021

Radboud university medical center study sets new milestone with 90% diagnostic accuracy of lung nodules suspected of cancer using Philips technology for bronchoscopic procedures

Hospital achieves world-first level of improvement in the diagnostic accuracy of navigation bronchoscopy using Philips Lung Suite combined with the company’s Image Guided Therapy System ­– Azurion

Amsterdam, the Netherlands – Royal Philips (NYSE: PHG, AEX: PHIA), a global leader in health technology, and Radboud university medical center (Radboudumc), a leading Dutch academic research and teaching hospital (Nijmegen, the Netherlands), have announced the positive results of a clinical study conducted by Radboudumc aimed at setting a new standard of safety and accuracy in the diagnosis of small peripheral lung lesions. The study outcomes represent a promising milestone in the global innovation effort to set a new clinical standard for detecting lung cancer at an early stage, potentially leading to improved prognoses for patients.

Radboudumc’s observational study reported the diagnostic accuracy and procedural radiation dose for patients undergoing an endobronchial lung biopsy supported by Philips Lung Suite – a solution that uses 3D imaging with augmented fluoroscopy to support high precision diagnosis and minimally-invasive therapy in one room. Diagnostic accuracy of 90% was reported while reducing the average total effective radiation dose per procedure by more than half from 47.5 Gy·cm2 (effective dose: 14.3 mSv) to 25.4 Gy·cm2 (effective dose: 5.8 mSv). The median long-axis diameter of the 248 lesions navigated to during the study was 13 mm (range 5-65mm). The results of the study were published in the October 2021 issue of the Journal of Bronchology & Interventional Pulmonology: Volume 28 – Issue 4 [1].

“The airways and lungs are very challenging places to biopsy, so we need good navigation to make sure we reach the target location,” said Dr. Erik van der Heijden, Pulmonologist and Associate Professor of Interventional Pulmonary Diseases at Radboudumc, who led the study. “Philips’ 3D imaging solution allows us to create real-time 3D visualizations enabling us to follow the correct path from different angles to where we need to be, which is particularly useful for very small abnormalities. Our study confirmed that it increases the accuracy and safety of the biopsy procedure, improving results for patients. Philips’ technology also offers the promising outlook that we could not only diagnose but also immediately treat these early-stage patients using novel procedures such as tumor ablation.”

Lung cancer – the leading cause of cancer death
Lung cancer kills around 1.7 million people a year worldwide. That makes it the leading cause of cancer death globally [2], accounting for greater loss of life than breast, colon, and prostate cancer combined. While early diagnosis and treatment are critical to better outcomes and quality of life, the majority of lung cancers are currently diagnosed at a late stage, with minimal chance of a surgical cure.

Early detection and diagnosis key to survivability
The research being carried out at Radboudumc focuses on the diagnosis of early-stage lung cancer lesions, typically detected during routine screening of high-risk patient groups or discovered and reported as so-called ‘incidental findings’ when a patient has a chest scan for some other reason. A tissue sample typically then needs to be obtained that a pathologist can use to make a definitive diagnosis.

Challenging for clinicians to accurately navigate
A new method is image-guided endobronchial lung biopsy, during which a clinician uses live image guidance to maneuver through the airways in the lungs to advance a catheter towards the lesion. However, the airways in the lungs are a complex network that requires accurate navigation to remove the required tissue sample. Until now, image-guided endobronchial lung biopsy has only really been effective when an abnormality or tumor is located in or near one of the larger airways in the lungs, and even then it is challenging for clinicians to accurately navigate when looking at a 2D greyscale fluoroscopy image while the lungs are moving as the patient breathes.

Philips Lung Suite enables all-in-one lung cancer diagnosis and treatment. It provides advanced real-time 3D imaging with augmented fluoroscopy on the company’s Image Guided Therapy System – Azurion, combined with dedicated software. With Philips’ Cone Beam CT imaging, the X-ray detector rotates around the patient to generate a CT-like image in around five seconds, providing clinicians with a high-resolution 3D view of the target lesion and other anatomical structures. This allows the clinician performing the biopsy procedure to be continually guided by high-quality real-time imaging to advance a catheter towards the lesion through a bronchoscope. Once done, its position can be confirmed in real-time using the same imaging modality and a biopsy sample removed.

Philips has a comprehensive portfolio of lung cancer diagnosis and treatment solutions. In addition to Philips Lung Suite, the company’s Lung Cancer Orchestrator provides an integrated lung cancer patient management system for both CT lung screening programs and incidental pulmonary findings programs that manages and monitors patients every step of the way in their lung cancer screening and treatment decision journey.

Read this interview with Dr. Erik van der Heijden on his personal experiences using Philips 3D imaging and navigation platform during image-guided endobronchial lung biopsy.

[1] Journal of Bronchology & Interventional Pulmonology: October 2021 – Volume 28 – Issue 4 – p 262-271 doi: 10.1097/LBR.0000000000000783
[2] CA CANCER J CLIN 2021;71:7–33, Cancer Statistics 2021: https://acsjournals.onlinelibrary.wiley.com/doi/epdf/10.3322/caac.21654

For further information, please contact:

Joost Maltha
Philips Global Press Office
Tel: +31 610 558 116
Email: joost.maltha@philips.com

Fabienne van der Feer
Philips Image Guided Therapy
Tel: +31 622 698 001
Email: fabienne.van.der.feer@philips.com

About Royal Philips
Royal Philips (NYSE: PHG, AEX: PHIA) is a leading health technology company focused on improving people’s health and well-being, and enabling better outcomes across the health continuum – from healthy living and prevention, to diagnosis, treatment and home care. Philips leverages advanced technology and deep clinical and consumer insights to deliver integrated solutions. Headquartered in the Netherlands, the company is a leader in diagnostic imaging, image-guided therapy, patient monitoring and health informatics, as well as in consumer health and home care. Philips generated 2020 sales of EUR 17.3 billion and employs approximately 77,000 employees with sales and services in more than 100 countries. News about Philips can be found at http://www.philips.com/newscenter