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ฐานข้อมูลความรู้ด้านเภสัชกรรม DrugBank ขยายความครอบคลุมสู่ประเทศไทย

เอ็ดมันตัน, อัลเบอร์ตา, May 31, 2021 (GLOBE NEWSWIRE) — DrugBank ฐานข้อมูลความรู้ด้านเภสัชกรรมที่สมบูรณ์และทันสมัยที่สุดในโลก ได้ขยายความครอบคลุมเพื่อให้บริการลูกค้าทั่วโลกได้ดียิ่งขึ้น โดยมีการเพิ่มภูมิภาคใหม่อีก 7 ภูมิภาคเพื่อนำเสนอผลิตภัณฑ์ ได้แก่ ออสเตรีย โคลัมเบีย อินโดนีเซีย อิตาลี มาเลเซีย ไทย และตุรกี นอกเหนือจากความครอบคลุมที่มีอยู่ของ DrugBank แล้ว ลูกค้าสามารถเข้าถึงชุดข้อมูลยาใหม่ๆ สำหรับผลิตภัณฑ์ยาและข้อบ่งใช้ยาเฉพาะสำหรับแต่ละภูมิภาคใหม่

“ด้วยการขยายเพิ่มใหม่นี้ ฐานความรู้ด้านเภสัชกรรมของเราจะสามารถเข้าถึงได้และครอบคลุมมากขึ้น” Mike Wilson, CEO ของ DrugBank อธิบาย “ซึ่งจะช่วยให้ลูกค้าใหม่ทั่วโลกสามารถเข้าถึงการนำเสนอผลิตภัณฑ์ของเราได้มากขึ้น และช่วยให้ลูกค้าเดิมขยายตัวสู่ตลาดใหม่ๆ”

สำหรับลูกค้าซอฟต์แวร์ทางคลินิก เช่น ผู้ที่อยู่ในอุตสาหกรรมเวชระเบียนอิเล็กทรอนิกส์ (EMR) ลูกค้าจะสามารถใช้ภูมิภาคท้องถิ่นของตนเป็นจุดเริ่มต้นของข้อมูลทางคลินิกที่มีโครงสร้างของ DrugBank ทั้งหมดได้

ผู้ที่ดำเนินงานในหลายภูมิภาคจะสามารถเข้าถึงข้อมูลทางคลินิกผ่านการผสานรวมของภูมิภาคต่างๆ ด้วย API เดียว ลูกค้าจำนวนมากขึ้นทั่วโลกสามารถค้นหาและจัดเก็บยาที่ทันสมัยได้เร็วขึ้นและมีความแม่นยำมากขึ้น

ยิ่งไปกว่านั้น ความครอบคลุมที่เพิ่มขึ้นจะช่วยให้ลูกค้าที่ให้การสนับสนุนการตัดสินใจทางการแพทย์ขั้นสูงสามารถใช้ชุดข้อมูลที่ละเอียดของ DrugBank สำหรับการวิเคราะห์ข้อมูลและการสร้างข้อมูลเชิงลึกได้ DrugBank แก้ปัญหาที่สำคัญตั้งแต่ขั้นแรกสำหรับผู้ใช้เหล่านี้ เนื่องจากเป็นการกำหนดข้อมูลยาหลายภูมิภาคให้เป็นมาตรฐานโดยการแมปข้อมูลไปยังตัวระบุทั่วไป และอัปเดตการแมปเหล่านี้เป็นระยะ

“เราเห็นลูกค้าจำนวนมากขึ้นเรื่อยๆ ที่ไม่เพียงต้องการเครื่องมือค้นหายา แต่ยังต้องดำเนินการวิเคราะห์ข้อมูลที่ซับซ้อนเพื่อเปิดเผยข้อมูลเชิงลึกและคาดการณ์เพื่อปรับปรุงผลลัพธ์ด้านสุขภาพอีกด้วย” Craig Knox, CTO ของ DrugBank กล่าว “ชุดข้อมูลที่มีโครงสร้างของเราช่วยให้ลูกค้าข้ามขั้นตอนที่มักใช้เวลานาน ได้รับประโยชน์จากข้อมูลที่มีอยู่มากขึ้น และรับข้อมูลเชิงลึกได้เร็วขึ้น”

สำหรับข้อมูลเพิ่มเติมเกี่ยวกับ Clinical API ของ DrugBank โปรดไปที่ www.drugbank.com/clinical

เกี่ยวกับ DrugBank

DrugBank เพิ่มพูนสติปัญญาของมนุษย์เพื่อพัฒนาสุขภาพผู้คนทั่วโลก เราส่งมอบชุดผลิตภัณฑ์ที่ช่วยให้บริษัทด้านการดูแลสุขภาพสามารถปรับปรุงการส่งมอบการดูแลสุขภาพผ่านยาที่มีความแม่นยำหรือแอปพลิเคชันซอฟต์แวร์ทางคลินิก พร้อมกับเปิดเผยข้อมูลเชิงลึกโดยการใช้วิทยาศาสตร์ข้อมูลกับการค้นพบยา DrugBank Online ที่เป็นแหล่งข้อมูลที่เข้าถึงได้สาธารณะของเรา ผ่านการอ้างอิงในสื่อพิมพ์ทางวิชาการมากกว่า 13,000 ฉบับและนักวิจัยและผู้เชี่ยวชาญด้านสุขภาพหลายล้านคนทั่วโลกไว้วางใจเลือกใช้

หากต้องการเรียนรู้เพิ่มเติมเกี่ยวกับ DrugBank โปรดไปที่ www.drugbank.com

ติดต่อประชาสัมพันธ์:
Kelvin Chen
Marketing Director, DrugBank
kelvin@drugbank.com

Pharmaceutical Knowledge Database DrugBank Expands Coverage To Thailand

EDMONTON, Alberta, May 31, 2021 (GLOBE NEWSWIRE) — DrugBank, the world’s most complete and up-to-date pharmaceutical knowledge database, expands coverage to better serve global customers. Seven new additional regions have been added to its product offering including Austria, Colombia, Indonesia, Italy, Malaysia, Thailand, and Turkey. On top of DrugBank’s existing coverage, customers can access new drug datasets for drug products and drug indications, specific to each new region.

“With these new additions, our pharmaceutical knowledge base becomes even more accessible and comprehensive,” explains Mike Wilson, CEO of DrugBank. “It allows new customers around the world better access to our product offerings, and helps existing customers grow into new markets”.

For clinical software customers, such as those in the electronic medical records (EMR) industry, they can use their local region as an entry point to the rest of DrugBank’s structured clinical information.

Those who operate in multiple regions can access clinical information through any combination of regions with one single API. More customers around the world can now search and store up-to-date medications faster and with more accuracy.

Moreover, the expanded coverage lets customers who provide advanced clinical decision support to use DrugBank’s detailed datasets for data analysis and insight generation. DrugBank solves a critical first step, for such users, as it normalizes multi-region medication data by mapping them to common identifiers, and keeps these mappings updated periodically.

“We are seeing more and more customers who not only need a drug lookup tool but perform complex data analysis to uncover insights and make predictions to improve health outcomes,” says Craig Knox, CTO of DrugBank. “Our structured datasets essentially help them skip an often time-consuming step, get more value out of their existing data, and get to insights faster.”

For more information about DrugBank’s Clinical API, visit www.drugbank.com/clinical

About DrugBank

DrugBank augments human intelligence to improve the world’s health. We offer a suite of products that enable healthcare companies to improve healthcare delivery through precision medicine or clinical software application, while uncovering insights by applying data science to drug discovery. Our publicly accessible resource, DrugBank Online, has been cited in over 13,000 academic publications and is used by millions of researchers and health professionals globally.

To learn more about DrugBank, visit www.drugbank.com

Press Inquiries:

Kelvin Chen
Marketing Director, DrugBank
kelvin@drugbank.com

Pakistan’s COVID-19 Positivity Rate Dips, But ‘We Aren’t Out of the Woods’, Official Tells VOA

ISLAMABAD – Pakistan reported Monday that the national coronavirus positivity rate had remained well below 5% over the past week, with the country’s top health official attributing the declining trend to “effective” government policies, including restrictions on public movement and effective screening of international travelers.

Officials recorded 43 deaths and detected more than 2,100 new cases in the last 24 hours, raising the national tally of deaths to nearly 21,000 and infections to more than 921,000 since the pandemic hit the South Asian nation early last year.

The national positivity ratio decreased to just over 4% from more than 11% a couple of weeks ago.

Last week, health authorities reported the detection of the first case of a fast-spreading variant of the coronavirus which has caused record infections and deaths in neighboring India, threatening Pakistan’s gains against the disease.

But Faisal Sultan, an infectious disease physician who is also special assistant to the prime minister on national health services, told VOA that an “effective” screening system for international travelers and other measures to deal with the health crisis have so far enabled the country to keep the situation under control in a country of about 220 million.

“I would say we are not out of the woods yet, but it seems at this point that I don’t foresee an India-like situation,” Sultan, who is directing all health-related interventions and measures against the pandemic, told VOA in a detailed interview at his office in Islamabad.

He noted that while his team has also detected a few cases of the variants prevalent in South African and Brazil, Pakistan is one of nearly 100 countries where a variant first detected in Britain, known as B117, is currently predominant.

“A large part of this wave that they [India] are going through, at least as best as I am aware, it was B117, and it was not necessarily the Indian variant that was doing it,” he said.

Vaccination drive

The Pakistani government announced Monday that later this week it would begin scheduling vaccinations for citizens 18 years old and above. The free national drive has so far inoculated more than seven million people, with officials reporting the number of daily vaccinations growing to fewer than 400,000.

Sultan said more than 70% of about 900,000 health care workers across Pakistan have been vaccinated so far. He added that the government intends to vaccinate 70% of the 100 million eligible population by the end of this year.

“We really do think that to reach our targets, we need to go over the 500,000 a day mark, perhaps the 600,000 a day mark. So, I think that we really need to ramp up our vaccinations.”

Sultan said government surveys have found that “at least two-thirds” of the Pakistani population is willing to get vaccinated.

“So, the vaccine centers will have to go close to their homes. It will have to be easy and accessible. It will have to be so easy that in the United States, even normal retail pharmacies were allowed to do the vaccination,” he said.

Sultan said the government really needed “to get at least a quarter of its population” in dense urban areas vaccinated before Pakistan “can even talk about any relaxation” in coronavirus-related restrictions, including asking those inoculated against the disease to remove their masks.

Health care system

Prime Minister Imran Khan’s government, which took office in August 2018, has from the outset focused on the country’s underfunded and largely neglected national health care system.

The focus, Sultan noted, enabled the government to timely position itself to combat the pandemic, despite critical economic challenges facing Pakistan.

“We added over 7,000 oxygenated beds into the health care system across Pakistan. The second expansion that was done is even more important — a 66% increase in the medical oxygen capacity was done. Had we not done that, we would have faced a crisis. We came to about 90% capacity in the ongoing third wave,” Sultan explained.

Pakistan initially received vaccine donations from close ally China to launch the national vaccination drive in early March before purchasing large quantities of vaccine doses to ensure supplies for the national campaign.

“They came out, gifted us the first lot, although we had told them we can pay for it. But they insisted. I think it speaks volumes about the level of trust and cooperation between China and Pakistan,” Sultan said.

The Pakistani government is using the Chinese-made Sinovac, Sinopharm and CanSino vaccines. It has also received just over a million doses of AstraZeneca under a United Nations-backed program for poor nations, known as COVAX.

Pakistani officials say they are in conversations with several suppliers, and the government will have procured about 20 million additional vaccine doses by end of July.

“The only challenge is, in an environment where everybody wants the vaccine, to have a steady supply so that you don’t run out of it. This is a challenge that will stay for the rest of the world,” Sultan said, noting that Pakistan was in talks with several suppliers to secure enough doses to sustain domestic supplies.

Beijing has also trained Pakistani staff and established a facility at Islamabad’s National Health Institute, where the one-dose CanSino vaccine is being filled from the concentrate provided by China. Sultan noted that the rare facility has the capacity to roll out about 3 million doses of CanSino a month to help boost the vaccination drive.

“It may be a small step for us that we have started filling the vaccine from concentrate. But it is a vital step toward actually manufacturing the vaccine in Pakistan, and I think it may take a few months,” he said.

Source: Voice of America

Climate Talks Resume Online as Pressure to Act Grows

PARIS – For the first time since 2019 and following a flurry of net-zero pledges from the world’s largest emitters, UN climate negotiations resume Monday in a virtual format just six months before the crunch COP26 summit.

The talks, nominally hosted by the United Nations climate change program in the German city of Bonn, will all be informal, meaning that no decisions will be taken during the three-week dialogue.

But with increasingly dire warnings from scientists that the pace of global warming is already outstripping humanity’s best plan to cut emissions, the pressure for progress to be made on several thorny issues is high.

In 2018, countries agreed to many elements of the Paris agreement “rulebook”, governing how each nation implements its goals.

But several issues remain unresolved, including rules about transparency, carbon markets, and a unified timeframe for all countries to ratchet up their emissions cuts.

At the last UN climate summit in December 2019, countries also failed to agree upon a universal system of reporting climate finance.

Nathan Cogswell, a research associate at the World Resources Institute, said a deal on greater transparency was “a central component of the effective implementation of the Paris agreement”.

“The upcoming session will hopefully help parties get closer to that.”

One of the thorniest debates during recent UN climate talks has been Article 6 of the Paris Agreement, which deals with the trade of emissions cuts.

A major sticking point remains over rules to avoid double counting emissions reductions within both bi-lateral and international carbon markets.

Some wealthy nations without the natural resources — forests, for instance — to mitigate their contribution to climate change have spent huge amounts on projects to preserve those habitats in other countries.

Currently both the buying and selling nations may count the project towards their domestic climate action, opening the door for the same cut to be counted twice.

Cogswell said that a failure to agree on a protection against double counting emissions reductions by the end of the COP26 in Glasgow in November would “weaken the ambition of global efforts” to fight climate change.

‘Not ideal’

COVID-19 forced Britain and the UN to shelve talks originally scheduled for last year until the end of 2021.

As the pandemic continues to rage, particularly among developing nations most vulnerable to the impacts of climate change, negotiators will need to achieve tangible progress during the three-week Bonn talks.

“The absence of a COP left a tremendous amount of work to be done… if we want to deliver at Glasgow,” said Marianne Karlsen, chair of a major technical forum at the UN-led negotiations.

The two-week sessions — expanded this year to three — normally involve thousands of representatives from more than 180 countries, and often rely on behind-closed-doors bargaining between delegates to get deals done.

Karlsen said the virtual configuration of talks was “not ideal at all”.

“We really wanted to be able to have all the interactions of when we meet in person but there was no other option,” she said.

Tosi Mpanu Mpanu, chair of the UN’s SBSTA technical working group, said delegates needed to use the virtual negotiations to “prioritize a way to capture progress, so we can capture that progress when we meet in person, and make decisions” in Glasgow.

“It’s important that we send a clear message to the world: We are very much engaged in resolving the Paris rulebook and to tackling this climate change conundrum.”

Source: Voice of America

Fueling Box Office Rebound, ‘Quiet Place’ Opens With $58.5M asso

NEW YORK – Moviegoing increasingly looks like it didn’t die during the pandemic. It just went into hibernation.

John Krasinski’s thriller sequel “A Quiet Place Part II” opened over the Memorial Day weekend to a pandemic-best $48.4 million, according to studio estimates Sunday. Including the Monday holiday, the studio forecasts the film will gross $58.5 million in North America. It added another $22 million in ticket sales overseas.

The film’s performance cheered a movie industry that has been punished and transformed by the pandemic. Paramount Pictures’ “A Quiet Place Part II,” which was on the cusp of opening in March 2021 before theaters shut, was the first big film this year — and one of the only larger budget COVID-era releases beside Christopher Nolan’s “Tenet” — to open exclusively in theaters.

Chris Aronson, distribution chief for Paramount, called the opening “an unqualified success.”

“It’s a huge sigh of a relief and a sense of optimism for sure,” Aronson said.

“Movies, moviegoing, movie theaters aren’t dead. Yes, they’ve been threatened but they’re proving once again that they’re resilient and that people do want to have that communal experience.”

Many studios have trotted out hybrid release plans during the pandemic, debuting films simultaneously in the home. The Walt Disney Co. did that this weekend with its live-action PG-13 Cruella De Vil prequel, “Cruella,” making it available to Disney+ subscribers for $30. In theaters, it grossed $21.3 million, Disney said, and an estimated $26.4 million over the four-day weekend. “Cruella” also added $16.1 million in 29 international territories. Disney didn’t say how much the film made on the company’s streaming platform.

“A Quiet Place II” will also turn to streaming after 45 days in theaters when it becomes available on Paramount+. One clear result of the pandemic is that the theatrical window has shrunk, probably permanently. Three months was once the customary length of a movie’s run in theaters. The year’s previous best debut belonged to Warner Bros.’ “Godzilla vs. Kong,” which opened with $32.2 million, or $48.5 million over its first five days, while simultaneously streaming on HBO Max.

The contrasting release strategies between “A Quiet Place Part II” and “Cruella” offered a test case for Hollywood. How much does a day-and-date release cost a movie like “Cruella” in ticket sales? Is it worth it? Without knowing how much “Cruella” benefitted Disney+, a true comparison isn’t possible. But the strong returns for the theater-only “A Quiet Place Part II” are telling, says Paul Dergarabedian, senior media analyst for data firm Comscore. He called it a “pivotal weekend” for the movie industry that proved predictions of the movie theater’s demise “flat-out wrong.”

“That ‘Quiet Place Part II’ did so well makes a strong case that a theatrical-first release for a big movie is the way to go,” Dergarabedian said. “This is the best possible news for an industry that’s been dealing with probably the most profoundly challenging chapter in the history of the movie theater.”

The debut of “A Quiet Place Part II” was much watched throughout Hollywood as the kickoff to its delayed summer movie season. After largely sitting out the pandemic, or diverting to streaming platforms, a lineup of blockbusters are again queuing up. On tap are Warner Bros.’ “In the Heights,” Universals’ “F9” and Disney’s “Black Widow.”

Last week, Universal Pictures’ ninth installment in the “Fast & Furious” franchise, “F9,” opened with $162 million in ticket sales in eight international markets, and $135 million in China alone. In its second weekend, “F9,” which opens in North America on June 25, raced toward $230 million worldwide.

“A Quiet Place Part II” had already had its red-carpet premiere in March last year, and spent some of its marketing budget. But it opened remarkably in line with predictions of how many tickets it would sell before the onset of the pandemic.

In the intervening months, Paramount sold off many of its films to streamers — “Coming 2 America,” “The Trial of the Chicago 7” — but Krasinski and the studio felt strongly that the hushed intensity of “A Quiet Place Part II” worked best on the big screen.

In an interview ahead of the film’s release, Krasinski said a theatrical release was “non-negotiable.” And Krasinski worked hard to stoke excitement, traveling the country in the week leading up to release to surprise moviegoers. Still, given the circumstances, he had little idea whether audiences would come out.

“As bizarre as the entire year has been is how bizarre whatever opening weekend is,” Krasinski said. “I don’t really know what it is anymore.”

In the end, “A Quiet Place Part II” performed a lot like how the first one did. That 2018 hit, which ultimately grossed $340 million globally on a $17 million budget, launched with $50.2 million in North American ticket sales. Sequels usually do better than the original but “Part II” had far more challenges due to pandemic.

Rich Gelfond, chief executive of IMAX, where “A Quiet Place Part II” earned $4.1 million domestically, called the film “the first domestic release this year to cross the threshold from ‘great opening weekend given the pandemic’ to ‘great opening weekend, period.'”

Memorial Day weekend, usually one of the busiest for theaters, still didn’t look like it normally does at the movies. Total box office exceeded $80 million but that’s about a third of the holiday weekend’s normal business. Last Memorial Day, when nearly all operating theaters were drive-ins, ticket sales amounted to $842,000, according to Comscore.

Many theaters, particularly in New York and Los Angeles, are still operating with social distancing measures. But guidelines are thawing. Last week, the nation’s top theater chains — AMC, Regal, Cinemark — said they would no longer require vaccinated moviegoers to wear face masks.

Source: Voice of America

More COVID Jabs to Be Distributed Globally in Coming Weeks

South Korean officials announced Sunday that a million doses of Johnson & Johnson COVID-19 vaccines would arrive in the country this week from the United States, doubling its earlier pledge.

Prime Minister Kim Boo-kyum said the shipment includes vaccines for 550,000 South Korean soldiers, as promised by U.S. President Joe Biden at his summit with President Moon Jae-in.

Authorities in India also said Sunday the country will have almost 120 million COVID-19 vaccine doses for domestic use next month, a significant increase from the 79.4 million available for the month of May.

India has inoculated with two shots only about 3% of its 1.35 billion people.

Meanwhile, Indian health officials reported Sunday the lowest daily rise of infections in 46 days.

In Malaysia, government announced it is planning to open more so-called mega vaccination centers, as the country marked a new daily record of COVID-19 infections.

Science Minister Khairy Jamaluddin told reporters in a virtual press conference Sunday that the government will set up five other centers around the capital, Kuala Lumpur, and possibly two in the northern state of Penang and in the southern state of Johor.

In Malaysia, a country of 32 million people, almost 6% of the population have been vaccinated, according to the data published by the governmental Special Committee for Ensuring Access to COVID-19 Vaccine Supply on its website.

In Brazil, tens of thousands of people took again to the streets in the capital, Brasilia, and other major cities to protest President Jair Bolsonaro’s handling of the coronavirus pandemic.

Some protesters in Rio de Janeiro marched through the streets, chanting “Bolsonaro genocide” or “Go away Bolsovirus.”

According to the Johns Hopkins University’s Coronavirus Resource Center, Brazil has the world’s second-highest death toll after the U.S., with over 461,000 and 594,300 respectively.

In Europe, France reported that Saturday the number of people in intensive care suffering from COVID-19 fell by 76 to 3,028 and the overall number of people hospitalized with COVID-19 decreased by 425 to 16,847.

Meanwhile, the European Commission has authorized the Pfizer-BioNTech COVID-19 vaccine for use in children as young as 12, widening the pool of those eligible to be inoculated, following similar approvals in the United States and Canada.

Germany and Italy have already said they are preparing to extend their vaccination campaign to youths ages 12 to 15.

Britain has approved a single-shot COVID-19 vaccine developed by Johnson & Johnson. It is the fourth COVID-19 vaccine approved in the country, after inoculations made by Pfizer, AstraZeneca, and Moderna.?

Source: Voice of America

WHO Calls for 20 Million COVID Vaccine Doses for Africa

GENEVA – The World Health Organization is asking for 20 million doses of COVID-19 vaccine for African countries to administer second doses to those who have received their first shot.

After three weeks of declining rates of COVID-19 infections in Africa, the World Health Organization is reporting an increase in cases. It says its latest figures of more than 4.7 million cases, including 128,000 deaths indicate a 17% rise over the previous week.

WHO regional director for Africa Matshidiso Moeti says she is concerned, but that it is too soon to tell whether Africa is on the cusp of a third wave.

“While it is too soon to say if Africa is seeing a resurgence, however, we are seeing increases in a number of countries, we are monitoring the situation very closely. And we see that we are balancing on a knife’s edge,” she said. “So this makes the rapid rollout of COVID-19 vaccines all the more important.”

Moeti says South Africa accounts for nearly one-third of the 65,000 new cases reported by WHO. She says she fears new variants of the virus circulating in South Africa may be spreading into neighboring countries. She notes Namibia and Zambia are among 11 African countries experiencing more cases.

So far, 28 million COVID-19 doses of different vaccines have been administered in Africa, a continent of 1.4 billion people. Moeti says Africa needs at least 20 million second doses of the Oxford-Astra Zeneca vaccine by mid-July to give everyone who has received the first dose full immunity.

“Africa needs vaccines now. Any pause in our vaccination campaigns will lead to lost lives and lost hope,” she said. “Another 200 million doses are needed so that the continent can vaccinate 10% of its population by September this year.”

Moeti appeals to countries that have vaccinated their high-risk groups to share their excess doses with Africa. She notes France is the first country to donate tens of thousands of doses to Africa from its domestic supply.

WHO says the European Union has pledged more than 100 million doses for low-income countries and the United States has promised to share 80 million doses with lower-income countries. Other wealthy countries have said they will follow suit.

Source: Voice of America