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Taconic Biosciences Expands Immuno-oncology Animal Model Portfolio

Critical Jh Syngeneic Tumor Model Host Now Available on a B6 Background

RENSSELAER, N.Y., Jan. 18, 2021 (GLOBE NEWSWIRE) — Taconic Biosciences, a global leader in providing drug discovery animal model solutions, announces an expansion of its immuno-oncology portfolio.

Immuno-oncology is a leading research priority because it uses the body’s own immune system to effectively treat some types of cancer. Syngeneic tumor animal models play a critical role because they use standard inbred mice that have a competent immune system, which is required to evaluate immune-modulating therapies. These models are engrafted with mouse tumors derived from the same strain background; this genetic similarity between tumor and host prevents the host from rejecting the tumor.

One consideration in using syngeneic models is that some drug candidates can cause a negative immune response not seen in humans.   Standard mice may develop anti-drug antibodies (ADA), which can neutralize the therapeutic or even trigger anaphylaxis. This can prevent researchers from determining therapeutic efficacy in a preclinical study.

Taconic’s Jh mouse, which lacks B cells but retains other immune cell types, such as T cells important for evaluation of immunotherapies, is widely used to overcome this problem. Because the Jh mouse cannot produce ADA, there is no neutralizing or pharmacokinetic impact on the therapeutic or anaphylaxis risk. Taconic’s Jh mouse was previously only available on the BALB/c background, so it was applicable to only a portion of syngeneic tumor studies. The new Jh mouse on the C57BL/6 background expands utility to cover most studies.

“Taconic is committed to both generating key immuno-oncology mouse models and facilitating access to them for drug discovery,” shared Dr. Michael Seiler, vice president of commercial models at Taconic. “The Jh mouse is available globally to both non-profit and for-profit researchers, including contract research organizations.”

Cohorts of both the C57BL/6 and BALB/c versions of the Jh mouse are available for immediate delivery.

The Jh models are just one aspect of Taconic’s immuno-oncology portfolio, which includes humanized mice built on the immunodeficient CIEA NOG mouse® plus custom model generation and colony management solutions.

To learn more about Jh mice, please contact Taconic at 1-888-TACONIC (888-822-6642) in the US, +45 70 23 04 05 in Europe, or email info@taconic.com.

About Taconic Biosciences, Inc.

Taconic Biosciences is a fully-licensed, global leader in genetically engineered rodent models and services. Founded in 1952, Taconic provides the best animal solutions so that customers can acquire, custom-generate, breed, precondition, test, and distribute valuable research models worldwide. Specialists in genetically engineered mouse and rat models, microbiome, immuno-oncology mouse models, and integrated model design and breeding services, Taconic operates three service laboratories and six breeding facilities in the U.S. and Europe, maintains distributor relationships in Asia and has global shipping capabilities to provide animal models almost anywhere in the world.

Media Contact:

Kelly Owen Grover
Director of Marketing Communications
518-478-6095
kelly.grover@taconic.com

Colliers Global Investor Outlook Report Anticipates Up To 50% Surge In Global Investment In 2021

New report reveals 98% of investors plan to expand their portfolios

TORONTO, Jan. 18, 2021 (GLOBE NEWSWIRE) — Leading diversified professional services and investment management firm Colliers International Group Inc. (NASDAQ and TSX: CIGI) reveals investors are largely optimistic about a market rebound in 2021, according to its new Global Capital Markets 2021 Investor Outlook. Colliers’ research anticipates a 50 per cent surge in investment activity in the second half of the year, pointing to a broad-based renewal of confidence in the property market as a result of recent vaccine developments and continued government stimulus.

“Based on our global analysis, which gives us a bird’s-eye view of investors’ interests and expected appetite, longer-term tailwinds in the property sector remain intact. With a massive volume of equity raised globally and the need for real assets, investors are eager to deploy pent-up capital and pursue opportunities during the year,” said Tony Horrell, Head of Capital Markets | Global at Colliers International. “We expect to see movement up the risk curve this year, with investors exploring all types of assets from senior care homes to public infrastructure projects.”

The report, which drew nearly 300 respondents including major institutional investors, listed property companies, sovereign wealth funds, private equity funds, family offices and third-party money managers, indicates 98 per cent of investors across all regions aim to expand their portfolios, with approximately 60 per cent looking to expand by more than 10 per cent. Furthermore, 67 per cent of survey respondents in EMEA and 88 per cent of those in the U.S. are planning their next investment as early as the first quarter of 2021.

Additional key takeaways from the Colliers Global Capital Markets 2021 Investor Outlook report include:

  • Top-tier city offices remain a primary asset target. Investors with international capital find the scale and liquidity of the office sector in major commercial hubs such as New York, London and Sydney appealing. Having office assets that meet health, sustainability and technical benchmarks is important to investors.
  • Logistics and living sectors are thriving. Both sectors were among investors’ top three choices across all regions. Intense demand for these assets will require investors to broaden their geographic focus and build portfolios through joint venture platforms and local partnerships.
  • Opportunities to repurpose discounted retail and hospitality assets. Investors are expecting to see pricing discounts of over 20 per cent in these sectors. They represent a rare opportunity to acquire core and distressed assets for ambitious repurposing initiatives.
  • Alternatives, platforms and partnerships are playing a bigger part. Rising demand for alternative assets such as data centres, senior living and life science assets reflects broader structural shifts amplified by the pandemic.

For more details, the full Colliers Global Capital Markets 2021 Investor Outlook is available for download at corporate.colliers.com.

About Colliers International

Colliers International (NASDAQ, TSX: CIGI) is a leading diversified professional services and investment management company. With operations in 68 countries, our more than 15,000 enterprising professionals work collaboratively to provide expert advice to maximize the value of property for real estate occupiers, owners and investors. For more than 25 years, our experienced leadership, owning approximately 40% of our equity, has delivered compound annual investment returns of almost 20% for shareholders. In 2019, corporate revenues were more than $3.0 billion ($3.5 billion including affiliates), with $33 billion of assets under management in our investment management segment. Learn more about how we accelerate success at corporate.colliers.com, Twitter @Colliers or LinkedIn.

MEDIA CONTACT:
Andrea Cheung
Global Manager, Communications
Andrea.cheung@colliers.com
416-324-6402

30V, 24×4 Dot Matrix LED Driver for Signage and Gaming Machines

10MHz Serial Bus with 8Bit PWM+ 8 Bit Analog Dimming enables rich RGB colors

30V, 24×4 Dot Matrix LED Driver for Signage and Gaming Machines

The IS31FL3748 is a new class of LED drivers designed for creating extremely bright and colorful LED-based signage board displays.

MILPITAS, Calif., Jan. 18, 2021 (GLOBE NEWSWIRE) — Lumissil Microsystems, a division of ISSI, today introduced the IS31FL3748, a new class of LED driver designed for creating extremely bright and colorful LED-based signage board displays. The IS31FL3748 is targeted for applications such as indoor or outdoor LED digital sign boards, zonal backlighting of LCD TV displays and attention grabbing RGB color lights for gaming machines.

The IS31FL3748 is firstly a software configurable 24×4 LED matrix driver which designers can use to create LED array sizes of up to 96 individually addressable LED dots. Each LED can be driven by a 0~40mA current, set by an external resistor and scalable through software registers. In addition each LED dot can be replaced by a number of serially connected LEDs. The result is instead of one individually addressable LED driven at 40mA; it is now possible to drive up to 9 Red LEDs or 7 of the Blue, Green or White LEDs in place of a single LED dot. The combined light output of multiple LEDs can then be used in large signs visible in daytime or used in dynamic zonal backlighting of LCD TFT displays or integrated into bright animated RGB color lights.

LEDs used for outdoor signage must compete with the sun for visibility. Viewing digital signs in daylight requires that LEDs output more light than typically required indoors so as to compensate for bright sun conditions. Obtaining a bright LED light can be accomplished by increasing the LED current or by increasing the number of LEDs. The IS31FL3748 addresses both of these requirements by supporting a 40mA current per LED and providing the capability for stacking many LEDs. Furthermore, multiple IS31FL3748 devices can be interconnected with a serial bus to expand the total display area. IS31FL3748 has three serial bus options; HSB (high speed series bus, up to 10MHz), DSB (Manchester encoded, daisy chained serial bus, up to 2MHz) or SPI (12MHz) bus.

“LED arrays are becoming the building blocks for interactive LED signage displays,” said Ven Shan, Vice President of Marketing. “With our latest IS31FL3748 LED matrix driver, sign developers and makers can create highly visible signs for advertising, information displays for transportation vehicles, transit terminals, sporting arenas and anywhere information needs to be displayed to the public. Other creative applications are for interactive LCD display backlighting and gaming machines found in casinos and pachinko parlors.”

The IS31FL3748 provides designers with increased system reliability and dynamic brightness control to enhance the visibility and long-term operation of large LED signboards. Power smoothing features such as LED group delay and system clock skewing minimize power supply stress and transient noise. Spread spectrum technology designed into the IS31FL3748 will further reduce EMI radiation. Additional analog and digital dimming capabilities such as 8-bit dot correction will help compensate for LED luminous mismatch and PWM control will adjust the display brightness.

Other reliability enhancement capabilities integrated into the IS31FL3748 are LED open or short detection and a thermal error flag. The device is designed to operate over a wide temperature range of -40°C to 125°C which is beyond the typical extended industrial temperature range.

Availability and pricing

The IS31FL3748 is available now in production quantities and comes in a 6x6mm 48-pin QFN package. It is priced at $1.25 each in 10K pcs quantities.

About Lumissil

Lumissil is the analog/mixed-signal product division of ISSI, a fabless semiconductor company that designs and markets high performance integrated circuits for the following key markets: (I) automotive, (ii) communications, (iii) industrial/medical, and (iv) digital consumer. Lumissil’s primary products are LED drivers for low to mid-power RGB color mixing and high power lighting applications. Other products include audio, sensor, high speed wired communications, optical networking ICs and Application-specific microcontrollers. ISSI/Lumissil is headquartered in Silicon Valley with worldwide offices in Taiwan, Japan, Singapore, China, Europe, Hong Kong, India, and Korea. Visit our web site at http://www.lumissil.com/

About Integrated Silicon Solution, Inc. (ISSI)

ISSI is a fabless semiconductor company that designs, develops and markets high performance SRAM, DRAM, Flash memory (including NOR flash, NAND flash and managed NAND solutions (eMMC)), and Analog/Mixed-signal integrated circuits. ISSI provides high-quality semiconductor products and has been a committed long-term supplier to its customers. ISSI is headquartered in Silicon Valley with worldwide offices in Taiwan, Japan, Singapore, China, Europe, Hong Kong, India, and Korea. Visit our web site at http://www.issi.com/

Ven Shan
P: 408-969-4622
vshan@lumissil.com
Aaron Reynoso
P: 408-969-5141
areynoso@lumissil.com

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/199278f3-bc1a-4b2e-a50d-a9b1edce2ce0

Six held for robbery, causing injury in JB

Police have arrested six people, including a local woman, on suspicion of being involved in a robbery incident and injuring a victim at a grocery store in the Ulu Tiram area near here on Friday.

Seri Alam Acting District Police chief DSP Shahrulanuar Mushaddat Abdullah Sani said the suspects, aged between 21 and 40, were arrested between 1 am and 6 am today through a series of raids and inspections of four houses in Taman Desa Tebrau, Masai and Pasir Gudang.

“Acting on intelligence and investigations, a team from the Criminal Investigation Division of the Seri Alam District Police Headquarters managed to arrest the five men and one woman.

“Police also managed to recover and seize various items for further investigation,” he said in a statement today, adding that all the suspects also tested positive for Methamphetamine.

All the suspects were also found to have criminal records, with two of them wanted under Section 15(1)(a) of the Dangerous Drugs Act 1952.

“Police also managed to recover the two mobile phones belonging to the victim as well as clothes worn by the suspects during the robbery. Also seized was a motorcycle with a fake registration number plate. Upon investigation, it was found that the motorcycle had been reported missing on the day of the robbery,” he said.

He said the case would now be investigated under Section 394 and Section 379A of the Penal Code for voluntarily causing hurt in committing a robbery and theft of a motor vehicle.

All the suspects have been remanded under Section 117 of the Criminal Procedure Code for further investigation as well as to identify and solve other cases that may have involved the six.

In the Jan 15 incident, which occurred at about 6 am, the suspects are believed to have robbed a 22-year-old male employee of the grocery store and also causing injury to his head with a machete.

Source: BERNAMA News Agency

Seven men arrested for obstructing, threatening police

The police have arrested seven men to facilitate investigations into an incident where a group of men surrounded and obstructed the police at a traffic light intersection in Tanjung Tokong here yesterday.

The group of men had alleged that the personnel of a police motorcycle patrol unit had deliberately kicked a motorcycle being ridden by two men, causing an accident to occur. They also provoked the three police personnel and insulted the authorities during the 5.20 pm incident.

Their actions went viral on social media and were condemned by netizens.

Meanwhile, when contacted by Bernama today, Penang CID chief SAC Rahimi Mohd Ra’ais confirmed the seven men’s arrest and said that they would be remanded tomorrow.

“The case is being investigated under Section 353 of the Penal Code for using criminal force to deter a public servant from discharging his duty, Section 506 of the Penal Code for criminal intimidation and Regulation 16 of The Prevention and Control of Infectious Diseases (Measures Within the Infected Local Areas) (Movement Control) Regulations 2021,” he said.

The police had previously denied that three of its personnel had kicked the motorcycle and causing the accident.

Northeast district police chief ACP Soffian Santong was reported to have said that initial investigations found that the police personnel were on a patrol along Jalan Sri Pinang when they came across a motorcycle ridden by two men without helmets. They then ordered them to stop for a check but the riders sped off trying to escape.

The police then chased them till the reached the intersection, where the two men chose not to stop and ran the red light before colliding with a car from town heading to Tanjung Bungah at the intersection.

Source: BERNAMA News Agency

Tawau cops detain five individuals, seize syabu worth RM1.5 Million

Police detained five individuals including two women, believed to be drug traffickers and seized 28.79 kilogrammes of syabu worth RM1.5 million in a raid last Thursday (Jan 14).

Tawau district police chief, ACP Peter Umbuas said the suspects, aged between 16 and 55, were nabbed through Op Benteng raid at 8 pm in an oil palm plantation area, Batu 10, Jalan Apas here.

“A police team from Tawau Police Criminal Investigation Department raided two vehicles behaving suspiciously.

“Upon inspecting one of the vehicles, police found a black bag containing 25 packages and a brown bag containing drugs,” he said in a press conference here today.

Peter said a preliminary investigation found that the drugs were believed to be smuggled into a neighbouring country and could be used by 140,000 drug addicts.

He said that urine test results showed all suspects were negative for drugs and they possessed no criminal records.

The five detained are now remanded for seven days since last Friday for further investigation under Section 39B of the Dangerous Drugs Act 1952,

In a separate development, Peter said residents in the Merotai, Bombalai and Kalabakan areas are urged to obtain approval letters from the nearest police stations before entering Tawau.

Source: BERNAMA News Agency

Govt have enough resources for public health system – Dr Adham

— The government is putting the people’s health as the top priority and has enough resources to ensure the public health system continues to serve the people to curb the spread of COVID-19, said Health Minister Datuk Seri Dr Adham Baba.

This was reflected in the announcement by Prime Minister Tan Sri Muhyiddin Yassin on PERMAI assistance package today, which clearly showed that the government gave the people’s health the highest priority, he added.

According to him, a total of RM800 million was allocated for the Health Ministry (MOH) to focus on supplies, including additional reagents, screening kits, sanitisers, consumables as well as personal protective equipment (PPE) specifically for healthcare frontliners.

The government is also deeply concerned with the higher workloads of frontliners and an additional 3,500 contract personnel including nurses and paramedics will be recruited at the end of this month, he said.

To integrate the country’s health service, Dr Adham said a total of RM100 million was allocated for cooperation with private hospitals to receive and treat both COVID-19 and non-COVID-19 patients to help alleviate the strain on the public healthcare system.

Dr Adham said MOH was also allocated RM3 billion for the preparation of the procurement of COVID-19 vaccine with the vaccination plan being scheduled to start by March this year at the latest.

“With the announcement of these measures, MOH calls on for all to fight the spread of the COVID-19 in an integrated manner,” he added.

Muhyiddin today unveiled the RM15 billion PERMAI assistance package with 22 initiatives to combat the pandemic, safeguard the welfare of the people and support business continuity.

Source: BERNAMA News Agency