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Sabin Vaccine Institute Receives $10M Grant to Raise Confidence in Vaccines

Three-year Grant to Support New Global Vaccine Acceptance and Demand Initiative

WASHINGTON, March 12, 2020 (GLOBE NEWSWIRE) — The Sabin Vaccine Institute (Sabin) today announced it has received a three-year grant valued at $10.4 million to strengthen vaccine acceptance. In 2019, the World Health Organization identified vaccine hesitancy – the reluctance or refusal to vaccinate despite the availability of vaccines – as one of the top 10 threats to global health.

Funding provided through a National Philanthropic Trust grant will launch Sabin’s new Vaccine Acceptance and Demand initiative and support several program areas: educating media and health care professionals on vaccines and immunization, supporting community-level social and behavioral research to understand vaccine acceptance and hesitancy, and enhancing understanding of social media influence on vaccination decisions.

The initiative is led by Sabin Global Immunization President Dr. Bruce Gellin who commented, “Vaccine hesitancy is creating a global health risk that must be addressed. Misinformation and disinformation about vaccines cost lives daily in communities around the world, as witnessed during the ongoing global measles resurgence. Through Sabin’s role at the intersection of immunization programs, policy and research, we will partner with local researchers, national immunization programs and other global health organizations to build evidence and provide the resources, connections and information stakeholders need to reverse this dangerous trend.”

Sabin CEO Amy Finan said, “Building on Sabin’s past work, our new Vaccine Acceptance and Demand initiative will expand the depth and breadth of our commitment to provide reliable information about vaccines to media and health professionals, while also expanding our understanding of vaccine acceptance decision making through both social media and social and behavioral research. Our ultimate goal is to build trust in vaccines so that patients are likely to accept vaccines and protect their health, as well as the health of their families and communities.”

Sabin’s Vaccine Acceptance and Demand initiative focuses on three interrelated work streams:

–  Communicate the importance and value of immunization and dispel vaccine misinformation by supporting media and health care professionals through Immunization Advocates. The new funding will expand Sabin’s existing program, which provides timely and accurate immunization information via online resources and tools, in-person workshops and access to knowledgeable immunization experts.

–  Following a successful pilot, launch programming to support researchers in low- and middle-income countries to improve vaccination acceptance through social and behavioral interventions with research grants and capacity-building activities. This work leverages Sabin’s existing Vaccination Acceptance Research Network.

–  Improve understanding of social media influence on vaccination decisions by working with social media researchers to define priorities and test interventions, with the goal of increasing vaccination acceptance.

About the Sabin Vaccine Institute
The Sabin Vaccine Institute is a leading advocate for expanding vaccine access and uptake globally, advancing vaccine research and development, and amplifying vaccine knowledge and innovation. Unlocking the potential of vaccines through partnership, Sabin has built a robust ecosystem of funders, innovators, implementers, practitioners, policy makers and public stakeholders to advance its vision of a future free from preventable diseases. As a non-profit with more than two decades of experience, Sabin is committed to finding solutions that last and extending the full benefits of vaccines to all people, regardless of who they are or where they live. At Sabin, we believe in the power of vaccines to change the world. For more information, visit sabin.org and follow us on Twitter, @SabinVaccine.

Media Contact:
Liz Powell

Study: Operator-Sponsored RCS Will Win Consumer Hearts and Brand Budgets

New findings reveal consumer appetite for advanced messaging functionality, but operators must place privacy, security and person-to-person functionality at the core of new messaging services

BRIDGEWATER, N.J., March 12, 2020 (GLOBE NEWSWIRE) — The United States is a market primed for operator-sponsored, brand- targeted advanced messaging based on Rich Communications Services (RCS), according to focus group conversations conducted by Synchronoss (NASDAQ: SNCR). After bringing together dozens of U.S. consumers of all ages to discuss their mobile messaging habits, Synchronoss is able to show the value of RCS to operators and brands to increase subscriber engagement and create new revenue.

RCS is an easy-to-use, feature-rich, interactive cross-operator advanced messaging platform that will be available on all mobile devices. This evolution of operator-led SMS messaging not only incorporates advanced multimedia capabilities into text messages but also gives users the ability to accomplish everything they currently do across multiple apps from a single messaging platform and with a single contact list for friends, family and services.

RCS also serves as a powerful, private-by-design direct marketing ecosystem that operators can offer to brands. Brands will be able to leverage a new secure, permission-based, personalized communications channel and take advantage of SMS’s higher open, response and click-through rates. At the same time, operators will gain an opportunity to grow their revenue outside of traditional lines of business and further solidify their own reputations as protectors of subscriber privacy.

Synchronoss, a global leader and innovator of cloud, messaging, digital and IoT products and the provider behind the RCS-based +Message service launched by three major Japanese operators in May 2018, asked focus group participants about their current messaging behavior and introduced them to RCS capabilities. The resulting discussions demonstrated a clear demand for operator-sponsored RCS, with convenience and operator trust at the heart of participants’ excitement for this new form of mobile communication.

“When asked about their perception of messaging services today, participants perceive a clear distinction between ‘messaging’ and ‘texting’,” said Glenn Lurie, President and CEO, Synchronoss. “‘Messaging’ is reserved for messaging applications, such as Facebook Messenger, WhatsApp or Instagram, while ‘texting’ is considered to sit outside of this messaging arena and is a different activity entirely. For consumers, texting is foolproof.”

For operators, this is good news. While consumers may use multiple messaging applications for different purposes, nearly everyone texts and they text a lot. Consumers trust traditional texting service because they consider it secure and reliable, and they know their personal contacts all have access to texting – which isn’t necessarily the case with messaging apps. In fact, the most commonly used messaging app is the native, pre-loaded application that integrates both SMS and device-centric messaging services, such as iMessage or Android Messages. This preference for and trust in SMS demonstrates a clear opportunity for operator-sponsored RCS to build on the allegiance consumers already have to text messaging.

RCS capabilities are wide-ranging. They include basic person-to-person chat as well as “mobile-app”-like experiences, such as booking and scheduling services or purchasing goods directly from the RCS application. Focus group members were receptive to the idea of living their digital lives in a single, one-stop messaging application that includes friends, family and favorite brands. They liked the prospect of being able to eliminate multiple apps and streamline their mobile communications into one all-encompassing tool. This removes the user-friction caused by the sometimes clunky and inconvenient separate messaging apps and the tendency of those apps to occupy a lot of device memory.

In addition to gaining a better understanding of consumers’ mobile messaging preferences, the research also produced some key findings for operators.

“Three lessons emerged from our research,” said Lurie. “First, operators must prioritize person-to-person communications to ensure RCS is seen as an app used for day-to-day texting as well as messaging. Second, operators should quickly launch application-to-person functionality to make it easy for consumers to control interactions with the brands they like. And finally, operators must prioritize privacy and security so that RCS becomes the app consumers trust for everything. RCS is an incredible opportunity for operators and brands. Consumers love its capabilities, and brands love its potential as a safe, engaging marketing channel.”

The findings from the focus groups can be found in a whitepaper entitled ‘How operator-sponsored RCS can win consumer hearts and brand budgets’, and can be downloaded here: https://synchronoss.com/operator-sponsored-rcs/

About Synchronoss Technologies, Inc.

Synchronoss (NASDAQ: SNCR) transforms the way companies create new revenue, reduce costs and delight their subscribers with cloud, messaging, digital and IoT products and platforms supporting hundreds of millions of subscribers across the globe. Synchronoss’ secure, scalable and groundbreaking new technologies, trusted partnerships and talented people change the way TMT customers grow their businesses. For more information, visit us at www.synchronoss.com.

Joseph Crivelli

Media Contacts:

Anais Merlin
CCgroup (International)
T: +44 20 3824 9200
E: synchronoss@ccgrouppr.com

Diane Rose
CCgroup (North America)
T: +1 202-350-2469
E: diane@ccgrouppr.com

Introducing Auth0 Signals: Threat Intelligence to Protect Customers from Widespread Identity Cyberattacks

Auth0 acquires Apility.io to integrate IP reputation in Anomaly Detection capabilities; and launches Auth0 IP Signals, a free standalone API for public use

BELLEVUE, Wash., March 12, 2020 (GLOBE NEWSWIRE) — Auth0, the identity platform for application builders, today launched Auth0 Signals, a collection of threat intelligence tools and product capabilities designed to protect customers from identity attacks. Auth0’s acquisition of Apility.io, an anti-abuse company, provides a crucial source of IP threat intelligence to Auth0’s Anomaly Detection engine, which detects malicious and risky login traffic to protect customers from automated attacks, such as credential stuffing and fake account creation. Auth0 IP Signals is a free tool available for anyone to use, and will be fully integrated into Auth0’s core authentication platform in Q2 2020.

Auth0 Signals provide important new sources of threat intelligence to Auth0’s Anomaly Detection engine, which already thwarts attacks from more than 50,000 unique IP addresses every day. The continual analysis of numerous risk signals – such as IP reputation, use of breached passwords, and failed authentication volume – assesses the risk of a transaction, login attempt, or session. The collective data gathered from Auth0 Signals produces a Confidence Score that Auth0’s platform then uses to prompt adaptive authentication, or intelligent and dynamic enforcement of controls, such as multi-factor authentication or blacklisting, based on risk.

Auth0 IP Signals is a curated and constantly updated IP address reputation search engine and API. Its threat database is constantly maintained via a variety of data sources across the web and deep web, including Open Source Intelligence (OSINT). It provides security practitioners with a comprehensive way to proactively identify fraudulent IP addresses and verify IP and email reputation, which can be used to prevent credential stuffing attacks and synthetic account creation. These types of attacks result in an average of more than $6 million a year in costs per company. Auth0 IP Signals is an extension of the company’s history of providing valuable resources for free to its loyal developer community.

“Security and availability are the top priority for our business. We integrated the Auth0 IP Signals API in just hours, and it started blocking abuse right away,” said Guillermo Rauch, CEO of ZEIT. “Auth0 Signals helps us ensure a great service to our customers, and helps save money and resources. The best part is that it continues to improve behind-the-scenes on its own.”

Gartner has introduced a Trusted Identity Corroboration Model (TICM) in its September 2019 Market Guide for Identity Proofing and Corroboration. According to Gartner, “TICM is a conceptual framework that assists SRM (Security & Risk Management) leaders to choose a set of tools and techniques that maximizes the collection of multiple risk indicators to identify fraudulent and malicious activity during account creation, access, and maintenance.” Further, “the continued reliance on static data, public records, or credit bureau data alone to either establish or substantiate trust in an identity is no longer simply unadvisable; it has become negligence. Likewise, a refusal to invest in the gathering and assessment of negative and positive signals puts the burden of security on customers, which is increasingly unacceptable in a world that demands frictionless and secure interactions with businesses and organizations.”1

As a central authentication and security service securing more than 100 million logins every day for enterprises around the globe, Auth0 has a unique vantage point for observing trends, where they originate from, and more importantly, knowing how to identify and block them before any damage is done. Recent internal data from Auth0 revealed that up to 67% of traffic going through Auth0 at any given time is suspicious, and 6% of IPs sending traffic to Auth0 are known to be blacklisted on the web, yet they are sending 50% of the total traffic to Auth0. Auth0 Signals will help block that fraudulent traffic from breaking into users’ accounts.

“Credential stuffing, password spraying, phishing, and other malicious attempts are constantly multiplying, and customers need more risk signals than any one company can provide, which is why we’ve created Auth0 Signals,” said Matias Woloski, CTO and co-founder of Auth0. “We have always been a developer-centric company, and wanted to provide a free resource to the application builder community for added value and security. By inserting threat intelligence and risk analysis into the IAM system, we’re reducing identity attack opportunities, offering a frictionless experience, and saving critical time and money for our customers.”

Apility.io is Auth0’s first acquisition, bolstering the company’s security strategy to protect against automated cyberattacks, and underscoring its focus on best security practices to keep customers’ information safe and their experiences seamless.

Additional Auth0 Signals threat intelligence tools will be launched in 2020, and will be freely available to security practitioners for proactive abuse prevention and incident investigation. To learn more, please visit: http://auth0.com/signals/ip.

About Auth0
Auth0 is the first identity management platform for application builders, and the only identity solution needed for custom-built applications. With a mission to secure the world’s identities so innovators can innovate, Auth0 provides the simplicity, extensibility, and expertise to scale and protect identities in any application, for any audience. Auth0 secures more than 100 million logins each day, giving enterprises the confidence to deliver trusted and elegant digital experiences to their customers around the world.

For more information, visit https://auth0.com or follow @auth0 on Twitter.

1 Gartner, “Market Guide for Identity Proofing and Corroboration,” Jonathan Care, Akif Khan, 30 September 2019

Media Contacts:
Jeana Tahnk
Auth0 Global Communications

Hannah Carroll
Matter for Auth0

Virtusa Named as the Top Challenger in the Everest Group’s PEAK Matrix Service Provider of the Year 2020

SOUTHBOROUGH, Mass., March 12, 2020 (GLOBE NEWSWIRE) — Virtusa Corporation (NASDAQ GS:VRTU), a global provider of digital strategy, digital engineering, and IT services and solutions that help clients change and disrupt markets through innovation engineering, announced it was named the top IT Services Challenger Star Performer in Everest Group’s PEAK Matrix Service Provider of the Year™ 2020 awards. Virtusa also increased its position as a Star Major Contender in the ITS Top 20 list.

The PEAK Matrix Service Provider of the Year ratings by Everest Group recognized consistent top performers across PEAK Matrix assessments. The Top 10 Challengers list recognized the top 10 IT service providers based on consolidated scores received on individual evaluations for Star Performer, Leader, Major Contender, and Aspirant positions throughout the year for companies with annual revenue of less than US $2 billion. The ITS Top 20 list ranked IT Service Providers using the same methodology, including companies with annual revenue exceeding US $2 billion.

“Virtusa’s recognition as the number one Challenger in the Everest Group Peak Matrix IT Service Provider of the Year 2020 ranking is both an honor and a validation of our strategy to drive the pace and success rate of digital transformation across industries,” said Kris Canekeratne, chairman and CEO, Virtusa. “The time is now for us and our unique ability to combine deep domain expertise, proprietary technologies, and digital engineering prowess in ways that deliver cloud-enabled end-to-end digital experiences and material top and bottom-line performance for our clients.”

To learn more about Virtusa, please visit: virtusa.com

About Virtusa Corporation

Virtusa Corporation (NASDAQ GS: VRTU) is a global provider of digital business strategy, digital engineering, and information technology (IT) services and solutions that help clients change, disrupt, and unlock new value through innovation engineering. Virtusa serves Global 2000 companies in the Banking, Financial Services, Insurance, Healthcare, Communications, Media, Entertainment, Travel, Manufacturing, and Technology industries.

Virtusa helps clients grow their business with innovative products and services that create operational efficiency using digital labor, future-proof operational and IT platforms, and rationalization and modernization of IT applications infrastructure. This is achieved through a unique approach blending deep contextual expertise, empowered agile teams, and measurably better engineering to create holistic solutions that drive business forward at unparalleled velocity enabled by a culture of cooperative disruption.

© 2020 Virtusa Corporation.  All rights reserved.

Virtusa is a registered trademark of Virtusa Corporation.  All other company and brand names may be trademarks or service marks of their respective holders.

Ron Favali

Philips becomes first medical device manufacturer granted new Underwriters Laboratories product cybersecurity testing firm registration

March 12, 2020

Amsterdam, the Netherlands – Royal Philips (NYSE: PHG, AEX: PHIA), a global leader in health technology, today announced that the company was named the first medical device manufacturer to receive a new Underwriters Laboratories (UL) product cybersecurity testing certification. Underwriters Laboratories (UL) is an independent global safety certification and testing company with locations worldwide.

The UL IEC 62304 certification was designed by Underwriters Laboratories to provide an overall framework to evaluate the robustness and maturity of a medical device manufacturer’s cybersecurity controls and capabilities for product development.

In support of the successful Philips firm registration for the security option of IEC 62304, UL performed a comprehensive audit of the Philips Security Center of Excellence. The Center was launched in 2015 to develop cyber-resilient products and services through security-by-design, risk assessment, vulnerability and penetration assessment, specialized trainings, and incident response.

The audit reviewed and verified core Philips product security processes, including security risk management and risk control measures, software security verification planning, change management and continuous improvement, and the Center’s laboratory quality management system.

The UL certification combines cybersecurity testing elements of the established UL 2900-2-1 standard for Software Cybersecurity for Network-Connectable Products, which focuses on the demanding requirements of healthcare and wellness systems, as well as security principles from international standards (ISO 13485 and ISO 14971).

“To receive this certification from Underwriters Laboratories, a long-established global leader in standards creation and safety testing, is a strong validation of our program and an opportunity to advance healthcare and personal health product security even further,” said Michael McNeil, Global Product Security & Services Officer, Philips.

“We’ve spent years building a successful and effective end-to-end Security by Design program, embedding security principles and best practices throughout a product’s life cycle,” McNeil added. “At Philips, we understand that our customers have high and growing expectations for the security of the solutions that they rely on. In addition, global regulatory authorities have also increased the scope and scale of product cybersecurity compliance requirements to help protect patients and consumers. We look forward to continuing to meet these critical commitments.”

For further information, please contact:

Mario Fante
Philips Global Press Office
Tel: +1 603-560=9226
E-mail: mario.fante@philips.com

About Royal Philips

Royal Philips (NYSE: PHG, AEX: PHIA) is a leading health technology company focused on improving people’s health and enabling better outcomes across the health continuum from healthy living and prevention, to diagnosis, treatment and home care. Philips leverages advanced technology and deep clinical and consumer insights to deliver integrated solutions. Headquartered in the Netherlands, the company is a leader in diagnostic imaging, image-guided therapy, patient monitoring and health informatics, as well as in consumer health and home care. Philips generated 2019 sales of EUR 19.5 billion and employs approximately 80,000 employees with sales and services in more than 100 countries. News about Philips can be found at www.philips.com/newscenter.


VistaJet Reports Record 2019 Results and Is Cautiously Optimistic for 2020 Despite the Unique Challenges Currently Faced Globally

VistaJet Global 6000

VistaJet Global 6000

The leading business aviation company records a 16% increase in flights on the back of a strong 2019 performance thanks to its proven business model

  • The Company recorded a strong start during first 10 weeks of 2020, notwithstanding the challenges posed by the coronavirus
  • Program membership in the U.S. continued to grow, registering a 24% increase
  • Particularly strong results in the Middle East with Members up 26%, flight hours up 24% and passengers up 35%
  • As part of Vista Global Holding, the Company is set to continue to take advantage of the fragmented business aviation sector with its global network of 115 owned business jets and over 1,700 aviation experts

LONDON, March 12, 2020 (GLOBE NEWSWIRE) — VistaJet, the first and only global business aviation company, starts 2020 with a market update amid the unique set of challenges posed by the coronavirus (COVID-19) as well as a recap of its solid growth during 2019 and the successes for the year.

The Company, with operations based in Malta, has made a positive start to 2020 as customers seek VistaJet’s commitment to security, flexibility of travel and privacy, which are not guaranteed by any other type of transport during times of instability. Early figures from January 2020 through today highlight that VistaJet’s total number of flights increased by a further 16% YOY and the Company continues to see strong demand across all regions. The U.S. registered the greatest number of flights during the first two months of the year, making up 23% of global flights. Despite the deep impact of the virus spreading across Asia, demand from the continent remains stable at 11%.

To safeguard passengers and crew, the Company has taken additional steps along with its partners to further strengthen safety and security procedures every day. Dedicated Flight Approval and Coordination teams are working 24/7 to assess and approve any booking and change requests from a technical, safety and security standpoint. To help reduce the spread of the virus, VistaJet works with leading experts, including Control Risks and Osprey for security and safety advice using both human and AI-driven intelligence, while MedAire provides leading medical support on the ground and in the air. All crew are checked for signs of the virus twice a day and each VistaJet aircraft is sanitized after every flight. As a precautionary measure, should authorities determine that a COVID-19 carrier traveled on a VistaJet aircraft, that tail and crew will be temporarily withdrawn from use. For upcoming bookings, passengers may be required to complete additional travel documents and health certificates, and those who have recently traveled to high risk locations may have their temperature tested prior to boarding.

Thomas Flohr, VistaJet’s and Vista Global’s Founder and Chairman, said:
“As the events of the last few months show, 2020 is not set to be business as usual. I have no doubt that the strong increase recorded over the past 10 weeks includes fliers looking for safer and cleaner alternatives to commercial flying. The agility and flexibility at the foundation of VistaJet ensure we are well-prepared to address the impact that the spread of coronavirus is having on the world.

“Above all else, the maximum safety and wellbeing of our passengers and crew is my utmost priority. The ever-changing developments associated with the coronavirus have guided us to find intelligent and innovative ways to step up to the challenge. We have been monitoring and adapting to the outbreak since the first cases were reported in late 2019, and we are working daily with experts and authorities to update our standards as the situation evolves.”

The Company’s 2020 pipeline comes on the back of a strong 2019, during which VistaJet made significant progress on its core strategic priorities and grew market share worldwide with a 21% growth in its Program membership.

Consistent with historical corporate trends, VistaJet increased its number of flights and passengers by double digits in 2019. Its new fleet optimization strategy catalyzed growth also during the low season of the first half, increasing global flights by 12% compared to the same time the previous year. Q3 2019 remained the most popular quarter, responsible for 28% of journeys.

The opening of a dedicated Middle East office drove the region to record the largest growth for the Company across number of flights, passengers and new clients joining the VistaJet Program — surging by 24%, 35% and 26% respectively. The UAE registered the majority of flights in the region and saw a 21% increase in flights, trailed only by Saudi for regional flights, which experienced a 41% growth.

The VistaJet Program model remained a favorable solution for U.S. based customers, recording a rise of 24% in the number of memberships in the market, while Asia’s membership grew by 6%, with China, India and Singapore leading the charge. Europe recorded an 11% growth in flight hours against 2018 figures and increased its Members in the market by 23%. The UK alone accounted for 24% of VistaJet’s flights in the region, proving that despite political uncertainties, the country continues to be a focus for global and European business.

VistaJet continued to lead the industry’s innovation and service, introducing more programs designed to elevate the experience for all clients. A new flight safety program launched at the beginning of the year pushed flight operations software to new heights with the adoption of Osprey Flight Solution’s data-led risk assessment technology. A partnership with Scuderia Ferrari as the official supplier of private jet travel throughout the Formula One season highlighted VistaJet’s promise of maximum speed and efficiency. The introduction of VistaPet, the leading global pet travel program in the aviation industry, set the high-water mark for four-legged passengers. The Company also announced VistaJet World — a comprehensive portfolio of one-of-a-kind, multi-tops travel adventure tailored around each Member’s passions.

VistaJet’s announcement, that it will be the first to get access to a fleet of Global 7500 aircraft starting in 2020, coupled with the synergies derived from Vista Global’s launch of XO, the global private aviation marketplace, ensures that the Company continues to be the leading asset-light alternative to aircraft ownership.

Thomas Flohr continues:
“VistaJet’s solutions are particularly attractive in times of uncertainty. The last 12 months were yet another milestone for the Company, Vista Global and XO; and I am proud of what we have achieved and that we continue to spearhead the industry in service excellence, innovation and global infrastructure. We begin 2020 positively during the first 10 weeks and I am looking forward to continuing to offer the best business aviation solution in this industry.”

Note to Editors:
Statements in this release are based solely upon information available as of the date of this release, are not a comprehensive statement of the Company´s financial results or positions as of or for the 2019 full year, and have not been audited, reviewed, or compiled by independent registered accounting firm. Therefore, the financial information in this release is preliminary, unaudited and subject to revision upon completion of the Company’s closing and audit processes. The Company assumes no obligation to update any information contained herein, save for any information required to be disclosed by law.

Jennifer Farquhar | VistaJet | T: +44 203 617 3077 | jennifer.farquhar@vistajet.com

About VistaJet
VistaJet is the first and only global aviation company. On its fleet of over 70 silver and red business jets, VistaJet has flown corporations, governments and private clients to 187 countries, covering 96% of the world. Founded in 2004, the company pioneered an innovative business model where customers have access to an entire fleet whilst paying only for the hours they fly, free of the responsibilities and asset risks linked to aircraft ownership. VistaJet’s signature Program membership offers customers a bespoke subscription of flight hours on its fleet of mid and long-range jets, to fly them anytime, anywhere.

VistaJet is part of Vista Global Holding – the world leading business aviation group, integrating a unique portfolio of companies offering asset-light solutions to cover all key aspects of business aviation.

More VistaJet information and news at vistajet.com

VistaJet and its subsidiaries are not U.S. direct carriers. VistaJet US Inc. and VistaJet Online and Mobile Services are air charter brokers that do not operate aircraft. VistaJet Limited is a European air carrier that operates 9H registered aircraft under its Maltese Air Operator Certificate No. MT-17 and is incorporated in Malta under Company Number C 55231. VistaJet-owned and U.S. registered aircraft are operated by properly licensed U.S. air carriers, including XOJET Aviation LLC.

A photo accompanying this announcement is available at https://www.globenewswire.com/NewsRoom/AttachmentNg/3adf10c9-f425-41db-ab8e-da5c7730987a

เปิดตัวต้นแบบหนูทดลองการเกิดพังผืดในตับสองรูปแบบใหม่โดย Crown Bioscience

ซานดิเอโก, March 12, 2020 (GLOBE NEWSWIRE) — Crown Bioscience ประกาศในวันนี้ถึงการเปิดตัวต้นแบบหนูทดลองพังผืดตับสองรูปแบบช่วยให้การประเมินผลกระทบก่อนนำไปใช้ในโรค NASH และการรักษาด้วยยาต้านการละลายลิ่มเลือดที่รวดเร็วและคุ้มค่ามากขึ้นสำหรับการบาดเจ็บที่ตับเฉียบพลัน การเกิดพังผืดขั้นรุนแรง และ/หรือการเกิดพังผืดผันกลับ

ทั้งสองต้นแบบครอบคลุมการเกิดพังผืดที่เกิดจากคาร์บอนเตตราคลอไรด์และอาหารต้านการเกิดผังผืดที่เพิ่มโคเลสเตอรอลและขาดโคลีน (CCDF) ใหม่ การเปิดตัวต้นแบบเหล่านี้ช่วยยกระดับความมุ่งมั่นของ CrownBio ในการพัฒนายาสำหรับโรค NASH โดยพัฒนารูปแบบการทดลองก่อนนำไปใช้ที่มีความหลากหลายยิ่งขึ้น

อาหาร CCDF ใหม่คืออาหารที่ปรับปรุงด้านการขาดโคลีน, ต้องการกรดอะมิโนชนิด L, มีไขมันสูง (CDAHFD) ที่ใช้ในการทดลองปัจจุบันก่อนนำไปใช้ โดยมีองค์ประกอบไขมันต่ำและเพิ่มคอเลสเตอรอล ผลลัพธ์จากหนู Wistar และต้นแบบหนูทดลอง C57BL/6 แสดงถึงอาการบาดเจ็บที่ตับอย่างรุนแรงกว่าหนูทดลองใน CDAHFD ด้วยการเกิดพังผืดที่สังเกตได้ในเวลาเพียงหกถึงเก้าสัปดาห์ และไม่มีการสูญเสียน้ำหนักที่เป็นอันตรายที่พบบ่อยในรูปแบบการขาดสารเคมีและขาดสารอาหารแบบดั้งเดิม

การเหนี่ยวนำคาร์บอนเตตร้าคลอไรด์ให้ต้นแบบเกิดพังผืดได้รวดเร็ว ช่วยให้ประหยัดเวลาและค่าใช้จ่ายในการศึกษาก่อนนำไปใช้เมื่อเปรียบเทียบกับต้นแบบที่มีภาวะโภชนาการเกินและต้นแบบที่ขาดสารอาหาร ภาวะพังผืดขั้นรุนแรงนั้นพบได้ในเวลาเพียงสี่สัปดาห์ในต้นแบบหนูทดลอง C57BL/6 และ Balb/c เมื่อเทียบกับ 16 สัปดาห์ขึ้นไปสำหรับอาหารโภชนาการเกินมาตรฐานอุตสาหกรรม

“พังผืดเกี่ยวข้องกับภาวะที่รุนแรงยิ่งขึ้นของโรค NASH ดังนั้น การพัฒนารูปแบบการทดลองใหม่เพื่อจำลองลักษณะของโรคนี้สามารถช่วยให้ผู้ป่วยที่ได้รับผลกระทบจากโรคที่มากับความเงียบนี้” Dr. Jim Wang รองประธานอาวุโสด้านโรคหัวใจและหลอดเลือดและโรคเกี่ยวกับการเผาผลาญที่ CrownBio กล่าว “ต้นแบบใหม่เหล่านี้พร้อมด้วยต้นแบบโรคตับอื่นๆ รวมถึง MS-NASH และ CCl4 ที่เหนี่ยวนำหรือปรับเปลี่ยนต้นแบบหนูทดลอง เช่นเดียวกับโมเดล NHP เพิ่มวิสัยทัศน์ของเราในการสร้างรูปแบบการทดลองชั้นนำในตลาดต้นแบบการทดลองที่จะนำไปใช้รักษาจริงระดับสูงเพื่อเร่งการค้นพบยาสำหรับโรค NASH”

CrownBio จะนำเสนอข้อมูลลักษณะเฉพาะของต้นแบบ CCDF อันล้ำสมัยที่เกิดขึ้นในหนู Wistar ในงาน NASH Summit ที่จะจัดขึ้นในบอสตัน ชื่อโปสเตอร์: ‘A Cholesterol Added, Choline Deficient Fibrogenic Diet Aggravates Liver Injury and Hepatic Steatosis in Wistar Rats’ จะนำเสนอต่อชุมชนวิทยาศาสตร์ NASH ในวันที่ 5 พฤษภาคม 2020

ในปลายปีนี้ CrownBio จะนำเสนอข้อมูลเกี่ยวกับต้นแบบ NHP ที่ได้รับการปรับปรุงใหม่ของไขมันพอกตับ, ไขมันในเลือดสูง และภาวะดื้อต่ออินซูลิน ช่วยเพิ่มความหลากหลายของต้นแบบที่มีให้กับผู้พัฒนายาสำหรับโรค NASH ความก้าวหน้าดังกล่าวจะช่วยให้การประเมินผลการรักษาที่มีศักยภาพที่ลดไตรกลีเซอไรด์ในตับและบรรเทาภาวะดื้อต่ออินซูลินในต้นแบบโดยสรุปความใกล้เคียงกับโรคด้านเมตาบอลิกในมนุษย์

เกี่ยวกับ Crown Bioscience Inc.

Crown Bioscience บริษัทเครือ JSR Life Sciences เป็นผู้ให้บริการด้านการพัฒนาและการค้นคว้ายาระดับโลกที่ส่งมอบรูปแบบการทดลองที่สามารถนำไปต่อยอดได้ เพื่อพัฒนาการวิจัยด้านมะเร็งวิทยา โรคด้านเมตาบอลิก และการอักเสบ ด้วยผลงานที่ครอบคลุมด้านโมเดลและเครื่องมือการคาดการณ์ที่เกี่ยวข้อง Crown Bioscience จึงทำให้ลูกค้าสามารถมอบการรักษาที่เหมาะสมได้อย่างเหนือชั้น



Jody Barbeau
Crown Bioscience Inc.